Corresponding author. To whom correspondence should be addressed. This article has been cited by other articles in PMC. Abstract Sex is an important factor in understanding the clinical presentation, management, and developmental trajectory of children with neuropsychiatric disorders. While much is known about the clinical and Model seks Woodbury profiles of males with neuropsychiatric disorders, surprisingly Gay huatulco Knoxville is known about females in this respect.
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Animal models may provide detailed mechanistic information about sex differences in autism spectrum disorder ASD in terms of manifestation, disease progression, and development of therapeutic options. This review aims to widen our understanding of the role of sex in autism spectrum disorder, by summarizing and comparing behavioral characteristics of animal models.
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Lovell-Badge and Robertson first described the four core genotypes FCG mice, characterized by the deletion of the testis-determining gene Sry from the Y chromosome XY females and the insertion of an Sry gene into the autosomes XX males [ 89 ]. The juvenile social play in FCG mice has been studied to determine sex differences and chromosomal effects in social interaction behaviors.
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In FCG mice, both wild-type male and female mice XX females and XY males have greater social behaviors than their heterochromosomal counterparts XY females and XX malesand the XY male group showed the highest social behavior compared to any other group. Indeed, the interaction of sex chromosomes and gonadal sex affects the social behavior in FCG mice, with the possible additional influence of sex hormones in social behaviors [ 10 ].
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